If you are not familiar with this study, it involved the use of a swine model. This is an area I am most proficient with. I was a veterinary technician before I became a nurse. I used to run the "pig labs" for clinical research and physician training for a major medical device company and have much experience in 510K clinical trials and was well regarded as a swine expert. I tell you my background only to hope you find validity in my critique.
My biggest problem is with the 300 lb.Yucatan pigs they used in the study. There are many categories of swine for use in experimental procedures and research with some being favored for one reason or another. The more proper Yucatan pig to use for any transdermal study is a Yucatan micro-pig (about 30 pounds) which has a skin thickness similar to that of human skin, and they are relatively hairless. This breed of pig was specifically bred in the swine labs at the Colorado State University in 1978.
I'm not certain as to why these researchers decided to use 300 pound Yucatan pigs with their incredibly thick skin and coarse hair. Perhaps they thought a pig was a pig. Perhaps they wanted to see if the Erchonia laser could penetrate steel... perhaps they know something about research pigs I don't My point is, there is more to this study than what seems to be "obvious" to some.
Here are two famous references I can direct you to to validate my statement that they used an inappropriate swine model:
1. Comparisons of in Vitro Nitroglycerine (TNG) Flux Across Yucatan Pig, Hairless Mouse, and Human Skins. Journal of Pharmaceutical Research. Springer Netherlands, publisher. ISSN: 0724-8741, Vol 7, Number 6. June 1990.
2. Fujii M, Yamanouchi S, Hori N, Iwanaga N, Kawaguchi N, Matsumoto M. Evaluation of Yucatan micropig skin for use as an in vitro model for skin permeation study. Biol Pharm Bull 1997 Mar; 20(3):249-54.
My other problems with the study include:
1. The pig underwent one ZERONA session, not the standard protocol of 6 (3 a week for 2 weeks).